abstract：:Highly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living with HIV and AIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study...

journal_title：Andrology

authors： Adana MY,Akang EN,Peter AI,Jegede AI,Naidu ECS,Tiloke C,Chuturgoon AA,Azu OO

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of castration and testosterone supplementation on nitroso-redox status, cardiac metabolism markers, and S100 proteins expression in the heart of male rats. 50 male Wistar rats were randomized into five groups with ten animals each: group 1: control intact (CON); gro...

journal_title：Andrology

authors： Regouat N,Cheboub A,Benahmed M,Belarbi A,Hadj-Bekkouche F

更新日期：2018-01-01 00:00:00

abstract：:Exosomes are membranous nanovesicles of endocytic origin that carry and transfer regulatory bioactive molecules and mediate intercellular communication between cells and tissues. Although seminal exosomes have been identified in human seminal plasma, their exact composition and possible physiologic function remain unk...

journal_title：Andrology

authors： Yang C,Guo WB,Zhang WS,Bian J,Yang JK,Zhou QZ,Chen MK,Peng W,Qi T,Wang CY,Liu CD

更新日期：2017-09-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate several functions of somatic cells. In a previous work, we reported FGFR expression in human spermatozoa and their involvement in motility. This study aimed to evaluate the presence and localization of fibroblast growth factor 2 (FGF2) in human sper...

journal_title：Andrology

authors： Garbarino Azúa DJ,Saucedo L,Giordana S,Magri ML,Buffone MG,Neuspiller F,Vazquez-Levin MH,Marín-Briggiler CI

更新日期：2017-09-01 00:00:00

abstract：:The use of intra-cytoplasmic sperm injection (ICSI) has increased significantly worldwide, often chosen instead of in vitro fertilization (IVF), yet long-term health outcomes are unknown and health differences between ICSI and IVF conceptions have not been comprehensively assessed. A systematic review of health outcom...

journal_title：Andrology

authors： Catford SR,McLachlan RI,O'Bryan MK,Halliday JL

更新日期：2017-07-01 00:00:00

abstract：:Scrotal skin is thin and has high steroid permeability, but the pharmacokinetics of testosterone via the scrotal skin route has not been studied in detail. The aim of this study was to define the pharmacokinetics of testosterone delivered via the scrotal skin route. The study was a single-center, three-phase cross-ove...

journal_title：Andrology

authors： Iyer R,Mok SF,Savkovic S,Turner L,Fraser G,Desai R,Jayadev V,Conway AJ,Handelsman DJ

更新日期：2017-07-01 00:00:00

abstract：:Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of interactions between GCNIS (germ cell neoplasia in situ) or seminoma cells and immune cells remain unknown. A co-culture model using the seminoma-derived TCam-2 cell line and p...

journal_title：Andrology

authors： Klein B,Schuppe HC,Bergmann M,Hedger MP,Loveland BE,Loveland KL

更新日期：2017-07-01 00:00:00

abstract：:In cryptorchid boys, failures in germ cell development have been clearly established. Some studies reported some abnormalities in Sertoli cells morphology but the results regarding their endocrine secretion remain controversial. To compare testicular hormone levels in young boys with and without cryptorchidism, we per...

journal_title：Andrology

authors： Hamdi SM,Almont T,Galinier P,Mieusset R,Thonneau P

更新日期：2017-07-01 00:00:00

abstract：:Deletions on the long arm of the Y chromosome are a well-known cause of male infertility and it is generally accepted that deletions involving the AZFb region are not compatible with sperm production. Here, we report on two patients for whom basic diagnostic tests showed a deletion of the AZFb region. Unexpectedly, bo...

journal_title：Andrology

authors： Stouffs K,Vloeberghs V,Gheldof A,Tournaye H,Seneca S

更新日期：2017-07-01 00:00:00

abstract：:Increasing evidence disclosed the existence of a novel multi-organ endocrine pathway, involving bone, pancreas and testis, of high penetrance in energy metabolism and male fertility. The main mediator of this axis is undercarboxylated osteocalcin (ucOC), a bone-derived protein-exerting systemic effects on tissues expr...

journal_title：Andrology

authors： De Toni L,Di Nisio A,Rocca MS,De Rocco Ponce M,Ferlin A,Foresta C

更新日期：2017-07-01 00:00:00

abstract：:A recent study has demonstrated that porcine spermatozoa recognize with high affinity carbohydrate structures containing Lewis X motifs. Sperm adhesion to Lewis X is proposed to mediate sperm binding to the oviduct epithelium to form a reservoir. The objective of this study was to identify Lewis X-binding proteins fro...

journal_title：Andrology

authors： Silva E,Frost D,Li L,Bovin N,Miller DJ

更新日期：2017-05-01 00:00:00

abstract：:Presence of vacuoles and degree of sperm DNA damage are considered to be the basic factors used for the assessment of sperm fertilization capacity. We aimed to investigate the link between these two parameters. According to our knowledge, this is the first study where the Comet assay was used to assess the degree of D...

journal_title：Andrology

authors： Pastuszek E,Kiewisz J,Skowronska P,Liss J,Lukaszuk M,Bruszczynska A,Jakiel G,Lukaszuk K

更新日期：2017-03-01 00:00:00

abstract：:Nitric oxide is a physiologic signal essential to penile erection. l-citrulline (l-Cit) is converted into l-arginine (l-Arg), the precursor from which nitric oxide is generated. The level of l-Arg and l-Cit in the field of male sexual function remains relatively underexplored. The aim of the study was to evaluate the ...

journal_title：Andrology

authors： Barassi A,Corsi Romanelli MM,Pezzilli R,Damele CA,Vaccalluzzo L,Goi G,Papini N,Colpi GM,Massaccesi L,Melzi d'Eril GV

更新日期：2017-03-01 00:00:00

abstract：:Cryoinjury is a consequence of cryopreservation and may have a negative impact on sperm quality regarding motility, morphology, and viability. This study was designed to identify potential proteomic changes in human sperm cells throughout the cryopreservation process. Comparisons made within this study included the de...

journal_title：Andrology

authors： Bogle OA,Kumar K,Attardo-Parrinello C,Lewis SE,Estanyol JM,Ballescà JL,Oliva R

更新日期：2017-01-01 00:00:00

abstract：:Sperm count, morphology, and motility have been reported to be predictive of pregnancy, although with equivocal basis prompting some authors to question the prognostic value of semen analysis. To assess the utility of including semen quality data in predicting conception delay or requiring >6 cycles to become pregnant...

journal_title：Andrology

authors： Patel CJ,Sundaram R,Buck Louis GM

更新日期：2017-01-01 00:00:00

abstract：:The second messenger cyclic adenosine monophosphate (cAMP) has a central role in sperm physiology. Extracellular cAMP can be sequentially degraded into 5'AMP and adenosine by ecto-phosphodiesterases (ecto-PDE) and ecto-nucleotidases, a phenomenon called extracellular cAMP-adenosine pathway. As cAMP-adenosine pathway i...

journal_title：Andrology

authors： Bergeron A,Aragon JP,Guillemette C,Hébert A,Sullivan R,Blondin P,Richard FJ

更新日期：2016-11-01 00:00:00

abstract：:Cell-free seminal RNA (cfs-RNA) is mixed transcripts derived from male reproductive organs, and is potential biomarker for the research and diagnosis of male reproductive-related diseases. However, some clinical factors, including age, asymptomatic Ureaplasma urealyticum (UU) infection, scrotal heat stress, abstinence...

journal_title：Andrology

authors： Dong TT,Yu Q,Qing XR,Ma XL,Dong WW,Shi J,Li HG

更新日期：2016-11-01 00:00:00

abstract：:The discontinuation rate with phosphodiesterase type 5 inhibitors (PDE5i) remains very high. The aim of this study was to review and meta-analyze currently available data regarding dropout of the first-generation of PDE5i including sildenafil, vardenafil, and tadalafil. An extensive Medline Embase and Cochrane search ...

journal_title：Andrology

authors： Corona G,Rastrelli G,Burri A,Serra E,Gianfrilli D,Mannucci E,Jannini EA,Maggi M

更新日期：2016-11-01 00:00:00

abstract：:Existing literature suggests evidence that protamine deficiency is related to DNA damage and male fertility. In this meta-analysis, we analyzed the relationship between the ratio of protamine-1 and protamine-2 with male fertility and the association of protamine deficiency with sperm DNA damage. Quality of available c...

journal_title：Andrology

authors： Ni K,Spiess AN,Schuppe HC,Steger K

更新日期：2016-09-01 00:00:00

abstract：:Semen analysis is commonly used as a tool to assess the fertility potential of a male, despite its relatively low predictive power. In this study, we have assessed associations between semen analysis findings (low count, low motility, low viability, poor sperm penetration assay results, poor morphology, and increased ...

journal_title：Andrology

authors： Jenkins TG,Aston KI,Hotaling JM,Shamsi MB,Simon L,Carrell DT

更新日期：2016-09-01 00:00:00

abstract：:Tamoxifen is an off-label option to treat men for breast cancer, infertility, and idiopathic gynecomastia. Lately, tamoxifen has been proposed as a treatment to prevent gynecomastia in prostate cancer patients receiving antiandrogen therapy. We reviewed the adverse events (AEs) reported in studies of men prescribed ta...

journal_title：Andrology

authors： Wibowo E,Pollock PA,Hollis N,Wassersug RJ

更新日期：2016-09-01 00:00:00

abstract：:The effects of equilibration times (E1, 2 h; E2, 4 h; E3, 6 h), freezing rates (FR1, manual, 5 cm above liquid nitrogen (LN2 ) for 10 min, plunging in LN2 ; FR2, programmable ultra-fast, holding at +4 °C for 2 min, from 4 to -10 °C at -10 °C/min, from -10 to -20 °C at -15 °C/min, from -20 to -120 °C at -60 °C/min, hol...

journal_title：Andrology

authors： Shah SA,Andrabi SM,Qureshi IZ

更新日期：2016-09-01 00:00:00

abstract：:Our objective was to study the birth defect rates in intracytoplasmic morphologically selected sperm injection (IMSI) pregnancies. A cohort of couples presenting male factor infertility between January 2006 and January 2014 was retrospectively analyzed. Discharge letters and a telephone interview were performed for as...

journal_title：Andrology

authors： Hershko-Klement A,Sukenik-Halevy R,Biron Shental T,Miller N,Berkovitz A

更新日期：2016-09-01 00:00:00

abstract：:Tributyltin (TBT), a pesticide used in antifouling paints, is toxic for aquatic invertebrates. In vertebrates, TBT may act in obesogen- inducing adipogenetic gene transcription for adipocyte differentiation. In a previous study, we demonstrated that acute administration of TBT induces c-fos expression in the arcuate n...

journal_title：Andrology

authors： Bo E,Farinetti A,Marraudino M,Sterchele D,Eva C,Gotti S,Panzica G

更新日期：2016-07-01 00:00:00

abstract：:Bisphenol A (BPA) is widely used in food contact materials, toys, and other products. Several studies have indicated that effects observed at doses near human exposure levels may not be observed at higher doses. Many studies have shown effects on mammary glands at low doses of BPA, however, because of small number of ...

journal_title：Andrology

authors： Mandrup K,Boberg J,Isling LK,Christiansen S,Hass U

更新日期：2016-07-01 00:00:00

abstract：:Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem w...

journal_title：Andrology

authors： Bechoua S,Hamamah S,Scalici E

更新日期：2016-05-01 00:00:00

abstract：:The morphology, ultrastructure, and functions of mature avian spermatozoa have been of immense commercial and scientific interest for several reasons. This is mainly important in case of birds in poultry production, conservation, and in the use of sperm morphometry as phylogenetic evidence. Avian spermatozoa share com...

journal_title：Andrology

authors： Majhi RK,Kumar A,Yadav M,Kumar P,Maity A,Giri SC,Goswami C

更新日期：2016-03-01 00:00:00

abstract：:Pubertal gynecomastia is a common condition observed in up to 65% of adolescent males. It is usually idiopathic and tends to regress within 1-2 years. In this descriptive cross-sectional study, we investigated 25 adolescent males with prominent (>B3) and/or persistent (>2 years) pubertal gynecomastia (P/PPG) to determ...

journal_title：Andrology

authors： Paris F,Gaspari L,Mbou F,Philibert P,Audran F,Morel Y,Biason-Lauber A,Sultan C

更新日期：2016-03-01 00:00:00

abstract：:Germ cell and Sertoli cell proliferation and maturation in human testes occur in three main waves, during the late fetal and early neonatal period and at early puberty. They are triggered by periods of increased activity of the hypothalamic-pituitary-gonadal (HPG) axis. In hypogonadotropic hypogonadism (HH), these pro...

journal_title：Andrology

authors： Rohayem J,Sinthofen N,Nieschlag E,Kliesch S,Zitzmann M

更新日期：2016-01-01 00:00:00

abstract：:Testosterone (T) deficiency, sexual dysfunction, obesity and obstructive sleep apnea (OSA) are common and often coexist. T prescriptions have increased worldwide during the last decade, including to those with undiagnosed or untreated OSA. The effect of T administration on sexual function, neurocognitive performance a...

journal_title：Andrology

authors： Melehan KL,Hoyos CM,Yee BJ,Wong KK,Buchanan PR,Grunstein RR,Liu PY

更新日期：2016-01-01 00:00:00

abstract：:Estrogens are involved in growth, differentiation and pathogenesis of human prostate through the mediation of the classical estrogen receptors ERα and ERβ. The G protein-coupled estrogen receptor (GPER) is a 'novel' mediator of estrogen signaling which has been recently recognized in some human reproductive tissues, b...

journal_title：Andrology

authors： Rago V,Romeo F,Giordano F,Ferraro A,Carpino A

更新日期：2016-01-01 00:00:00

abstract：:The double sex and mab-3-related transcription factor 1 (DMRT1) gene has long been linked to sex-determining pathways across vertebrates and is known to play an essential role in gonadal development and maintenance of spermatogenesis in mice. In humans, the genomic region harboring the DMRT gene cluster has been impli...

journal_title：Andrology

authors： Lima AC,Carvalho F,Gonçalves J,Fernandes S,Marques PI,Sousa M,Barros A,Seixas S,Amorim A,Conrad DF,Lopes AM

更新日期：2015-09-01 00:00:00

abstract：:In this study a Bayesian network (BN) has been built for the study of the objective motility of Tinca tinca spermatozoa (spz). Semen from eight 2-year-old sexually mature male tenchs was obtained and motility analyses were performed at 6-17, 23-34 and 40-51 s after activation, using computer-assisted sperm analysis (C...

journal_title：Andrology

authors： Gil Anaya MC,Calle F,Pérez CJ,Martín-Hidalgo D,Fallola C,Bragado MJ,García-Marín LJ,Oropesa AL

更新日期：2015-09-01 00:00:00

abstract：:Erectile Dysfunction is considered a multifactorial disease, where organic and psychological aspects are often interconnected. In a randomized controlled pilot study, we compared the efficacy of combined vardenafil orodispersible tablet (VARD) and cognitive-behavioral sex therapy (CBST) vs. VARD alone in improving sex...

journal_title：Andrology

authors： Boddi V,Castellini G,Casale H,Rastrelli G,Boni L,Corona G,Maggi M

更新日期：2015-09-01 00:00:00

abstract：:Male factor etiology may be a contributing factor in up to 60% of infertility cases. Dietary intake of phytoestrogens has been related to abnormal semen quality and hormone levels. However, its effect on couple fecundity is still unclear. Intake of soy products was assessed in 184 men from couples undergoing infertili...

journal_title：Andrology

authors： Mínguez-Alarcón L,Afeiche MC,Chiu YH,Vanegas JC,Williams PL,Tanrikut C,Toth TL,Hauser R,Chavarro JE

更新日期：2015-07-01 00:00:00

abstract：:Peyronie's disease (PD) is an under-diagnosed condition with prevalence in the male population as high as 9%. It is a localized connective tissue disorder of the penis characterized by scarring of the tunica albuginea. Its pathophysiology, however, remains incompletely elucidated. For the management of the acute phase...

journal_title：Andrology

authors： Yafi FA,Pinsky MR,Sangkum P,Hellstrom WJ

更新日期：2015-07-01 00:00:00

abstract：:Sperm DNA fragmentation varies between individuals and is more pronounced with increased patient age and time after sperm donation. The intensification of DNA fragmentation depends on the balance of the oxidoreductive system, which is regulated mainly by two enzymes - superoxide dismutase (SOD) and catalase. The objec...

journal_title：Andrology

authors： Wdowiak A,Bakalczuk S,Bakalczuk G

更新日期：2015-07-01 00:00:00

abstract：:Humanin (HN) has cytoprotective action on male germ cells after testicular stress induced by heat and hormonal deprivation. To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP...

journal_title：Andrology

authors： Surampudi P,Chang I,Lue Y,Doumit T,Jia Y,Atienza V,Liu PY,Swerdloff RS,Wang C

更新日期：2015-05-01 00:00:00

abstract：:Most of the non-obstructive azoospermia (NOA)-patients have only focal spermatogenesis which results in insufficient numbers of spermatozoa to reach the ejaculate. In ≈50% of these NOA-patients testicular sperm extraction (TESE) is successful and intracytoplasmic sperm injection (ICSI) is pursued. We studied whether (...

journal_title：Andrology

authors： Hessel M,de Vries M,D'Hauwers KW,Fleischer K,Hulsbergen-van de Kaa CA,Braat DD,Ramos L

更新日期：2015-05-01 00:00:00

abstract：:Urethral stricture disease, pelvic fracture urethral injury (PFUI), and their various treatment options are associated with erectile dysfunction (ED). The etiology of urethral stricture disease is multifactorial and includes trauma, inflammatory, and iatrogenic causes. Posterior urethral injuries are commonly associat...

journal_title：Andrology

authors： Sangkum P,Levy J,Yafi FA,Hellstrom WJ

更新日期：2015-05-01 00:00:00